Registration Dossier
Registration Dossier
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EC number: 205-205-0 | CAS number: 135-61-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3-hydroxy-2'-methyl-2-naphthanilide
- EC Number:
- 205-205-0
- EC Name:
- 3-hydroxy-2'-methyl-2-naphthanilide
- Cas Number:
- 135-61-5
- Molecular formula:
- C18H15NO2
- IUPAC Name:
- 3-hydroxy-N-(2-methylphenyl)naphthalene-2-carboxamide
- Reference substance name:
- Naphtol AS-D
- IUPAC Name:
- Naphtol AS-D
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Interfauna UK
- Age at study initiation: 3-5 months
- Weight at study initiation: 2.8 - 3.1 kg
- Housing: single
- Diet: ad libitum
- Water : ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20+/- 3
- Humidity (%): 50 +/- 20
- Photoperiod (hrs dark / hrs light):12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: PEG 400
- Controls:
- not required
- Amount / concentration applied:
- 500 mg / 0,4 ml vehicle per animal
- Duration of treatment / exposure:
- 4h
- Observation period:
- 72 h
- Number of animals:
- 3
Results and discussion
In vivo
Results
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible
- Remarks on result:
- other: Animals 2 & 3 did not show effects at all
- Other effects:
- none reported
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Naphtol AS D was not irritating on the skin of rabbits.
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