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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Link to relevant study record(s)

bioaccumulation in aquatic species: fish
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Study period:
August 2018
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
no guideline required
Principles of method if other than guideline:
BCF was calculated using a model calculation recommended by EC and ECHA guidance.
GLP compliance:
Key result
238.23 L/kg
Remarks on result:
other: BCF was calculated using a model calculation recommended by EC and ECHA guidance.

The log Kow of BPA PO was determined to be 3.62 in a key study carried out in accordance with OECD Guideline No. 117. Therefore, use of a linear model is considered suitable to calculate the BCF concentration factor for BPA PO. Veith et al. (1979) developed the following QSAR to calculate BDF based on a data set of 55 neutral non-ionized substances with a log kow value range of 1 - 5.5:

log BCF(fish) = 0.85 x log Kow − 0.70

(R2 = 0.897)

Applying this formula to BPA PO, an estimated BCF of 238 L/Kg ww is obtained:

Log BCF(fish) = 0.85 x 3.62 – 0.70

Log BCF(fish) = 2.377

BCF(fish) = 238.23 L/Kg ww

Validity criteria fulfilled:
not applicable
The BCF in fish was calculated to be 238 L/Kg ww.
Executive summary:

In the absence of any available experimental data on the bioaccumulation of BPA-PO, a BCF was calculated based on the log Kow value of the substance in order to avoid unnecessary testing on animals. An estimated BCF(fish) of 238 L/Kg ww was calculated using a linear model developed by Veith et al. (1979) which performs well for substances with a log Kow of <6 (ECHA, 2017). The estimated BCF indicates the substance has a limited bioaccumulation potential and further testing is therefore not considered necessary.

Description of key information

Based on the measured log Kow values and the estimated corresponding BCF values it can be concluded that the substance has limited bioaccumulation potential. Further testing is therefore not considered necessary. The BCF in aquatic organisms was estimated using the Veith relationship which is also incorporated in EUSES and is applicable for substances with a log Kow up to 6: log BCF = 0.85 log Kow - 0.70. This results in an estimated BCF of 229.  

Key value for chemical safety assessment

BCF (aquatic species):
229 L/kg ww

Additional information