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Physical & Chemical properties

Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
GLP compliance:
no
Remarks:
Conducted in a GLP compliant laboratory but not as part of a formal GLP study
Type of method:
method to determine freezing temperature
Remarks:
freezing assessed visually
Melting / freezing pt.:
< -20 °C
Remarks on result:
other: No further information was provided.

After 24 hours the samples were checked visually to see whether they had frozen or not. On the first check it was found that only the -80°C weighing had frozen. It was decided to seed a -20°C sample with some frozen samples from the weighing kept at -80°C. This was left for another 24 hours after which it was found to still be unfrozen. As the freezing point was found to be between -20°C and -80°C no further analysis was carried out and the freezing point was reported as <-20°C.

Conclusions:
The testing was performed to a minimum temperature of -20°C. The substance remained a liquid, despite being seeded with frozen sample from the -80°C weighing and left for 24 hours. The melting/freezing point was therefore reported as <-20°C.
Executive summary:

The melting point of the test substance was determined in accordance with the EU Testing Method A.1. The melting point was determined by weighing out three lots of 1 g of sample and placing at either 4°C, -20°C or -80°C. The samples were left for 24 hours and assessed visually to see whether they had frozen. After the first check only the -80°C sample had frozen. The -20°C was seeded with some -80°C sample and left for a further 24 hours. After the second 24 hour period the -20°C sample was still liquid. As the freezing point was found to be between -20°C and -80°C no further testing was conducted and the melting/freezing point was therefore reported as <-20°C.

Description of key information

The melting point of the test substance was determined in accordance with the EU Testing Method A.1. The melting point was determined by weighing out three lots of 1 g of sample and placing at either 4°C, -20°C or -80°C. The samples were left for 24 hours and assessed visually to see whether they had frozen. After the first check only the -80°C sample had frozen. The -20°C was seeded with some -80°C sample and left for a further 24 hours. After the second 24 hour period the -20°C sample was still liquid. As the freezing point was found to be between -20°C and -80°C no further testing was conducted and the melting/freezing point was therefore reported as <-20°C.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
-20 °C

Additional information