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Ecotoxicological information

Long-term toxicity to fish

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Description of key information

In a reliable guideline study, the 28 d NOEC of C12-16 ABDAC for hatchability of Fathead minnow eggs was 0.273 mg a.i./L. The 28 d NOEC for survival was 0.0322 mg a.i./L and the 28 d NOEC for growth was > 0.0322 mg a.i./L.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater fish:
0.032 mg/L

Additional information

A guideline study was conducted to determine the effect of C12-16 ADBAC on toxicity, mortality, hatchability and growth of Fathead minnow (Pimephales promelas). Fathead minnow eggs (80 per concentration) were exposed to mean measured concentrations of 0, 32.3, 75.9, 134.2, 186.8, 273.2 and 488.7 mg a.i./L of the radiolabelled test substance. Analytical determination was performed and the sample concentrations were verified by liquid scintillation counting. After 7 days, surviving fry from two replicates were thinned to 10 animals per replicate for each exposure group (total of 20 animals per concentration) and exposed to the same concentrations for a 28 day post-hatch static renewal toxicity test. Observations of symptoms and mortality were conducted daily. Under the conditions of the study, the 28 d NOEC for hatchability was 0.274 mg/L, the 28 d NOEC for survival was 0.0322 mg a.i./L and the 28 d NOEC for growth was > 0.0322 mg a.i./L) (McIntyre DO and Pate HO, 1992).