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EC number: 248-205-6 | CAS number: 27070-58-2
In an acute toxicity study, eight homologous series of n-alkenes (n-olefins), including 1-hexene, were evaluated for their potential to cause acute toxicity using an aspiration process. Groups of 5 anesthetized male albino Wistar rats were either administered 0.2 millilitre or 1 millilitre of liquid or aerosolized test material respectively into the mouth. When breathing resumed and was regular after test material administration, the animals’ nostrils were closed with fingers during the end of expiration phase to promote aspiration of the test material. This process was repeated until all of the test material had been aspirated. After dosing, animals were observed for a minimum of 4 hours at intervals ranging from 5 to 30 minutes. Animals that survived for 24 hours were sacrificed and lungs were weighed and received gross necropsy.
Three rats receiving 1 -hexene died within 24 hours. Additionally, rats dosed with 1 -hexeneexhibited central nervous system effects.Lung weights of these animals did not differ significantly form control animals.Study authors reported that grossly, pathologically, lungs of these animals displayed typical "liver-like lungs."
A quantitative estimate of acute toxicity was not reported for this study.Based on the study outcome, the study authors concluded that 1-hexene is toxic when aspirated causing rapid death in 3 of the five treated animals. Two of the live animals reportedly did not aspirate any test material since 1-hexene "boiled out of the mouth" before it was aspirated.
This study received a Klimisch score of 2 and is classified as “reliable with restrictions”because although the study was well conducted, there is no statement regarding whether this study was conducted according to GLP or equivalent.
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