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Description of key information

As outlined in attached toxicokinetic assessment homosalate can be well absorbed via the oral route of exposure (100% assumed) but less well by dermal route (<10% assumed). Inhalative exposure is not relevant due to low  vapour pressure. No accumulation in the body is expected due to efficient metabolic pathways and formation of soluble degradation products (salicylic acid and trimethylcyclohexanol being mainly excreted as glucuronic acid conjugates) with established elimination routes. 

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - oral (%):
100
Absorption rate - dermal (%):
10

Additional information

Homosalate can be well absorbed via the oral route of exposure (100% absorption assumed), but not well via the dermal route (less than 10% assumed).

Due to the low vapor pressure for this liquid (Intertek ASG, 2011), the inhalation route is not considered to be a relevant exposure route to human for this substance.

Following absorption homosalate is metabolized to salicylic acid and trimethylcyclohexanol rapidly. Salicylic acid is mainly excreted by renal excretion as an unchanged chemical entity or after conjugation with glycine as salicyluric acid. Trimethylcyclohexanol is mainly excreted as glucuronic acid conjugates. Glucuronides and degradation products are mainly eliminated via urine, minor quantities via the faeces. Hence, bioaccumulation in the human body is not expected, as outlined in attached toxicokinetic assessment.