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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2010-03-05 to 2010-03-26
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
no
Type of method:
column elution method
Water solubility:
< 0.05 mg/L
Temp.:
20 °C
pH:
6.84

Quantitative determination of the analyte

Flow rate (mL/h)

Fraction No.

Water solubility of test item, mg/L

pH value

25

1 (1-2)

< 0.05

7.0

 

2 (3-4)

< 0.05

6.9

 

3 (5-6)

< 0.05

6.8

 

4 (7-8)

< 0.05

6.8

 

5 (9-10)

< 0.05

6.9

 

6 (11-12)

< 0.05

6.8

 

7 (13-14)

< 0.05

6.9

 

 

 

 

12.5

1 (1-2)

< 0.05

7.1

 

2 (3-4)

< 0.05

6.8

 

3 (5-6)

< 0.05

6.8

 

4 (7-8)

< 0.05

6.7

 

5 (9-10)

< 0.05

6.7

 

6 (11-12)

< 0.05

6.8

 

7 (13-14)

< 0.05

6.8

Linearity

Linearity could be shown over the calibration range from 0.05 to 5.5 mg/L (correlation coefficient R = 0.999).

Recovery

In a duplicate analysis, a recovery rate of 100% was ascertained.

Description of key information

< 0.05 mg/L at 20 °C, pH = 6.84

Key value for chemical safety assessment

Additional information

The water solubility of the substance 1,2 -Benzenedicarboxylic acid, di-C16 -18 -alkyl esters (CAS 90193 -76 -3) was determined according EU method A.6 using the column elution method.