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EC number: 295-405-4 | CAS number: 92045-23-3 A complex combination of hydrocarbons produced by the distillation of the products of a steam cracking process. It consists predominantly of hydrocarbons having a carbon number of C4, predominantly 1-butene and 2-butene, containing also butane and isobutene and boiling in the range of approximately minus 12°C to 5°C (10.4°F to 41°F).
Concentrations of individual 1-alkenes after the third 12 h exposure to 300 ppm and concentrations in fat 12 h after the final exposure
Fat 12 h elim
N=4, mean +/- SD
All concentrations are in µmol/kg; nd = not detectable
Adjustment factors for exhalatory loss of C2 -C4 1 -alkenes ranged from 1.00 to 1.10.
Mean levels of N-(2-hydroxyalkyl)valine in haemoglobin (pmol/g) and 7-alkylguanine adducts in lymphocytes and liver (adducts/107normal nucleotides) formed after exposing rats to the 1-alkenes.
Background values have been subtracted
N = 3-8 for haemoglobin and 4 for DNA adduct analysis
The absorption, distribution, elimination, haemoglobin adduct formation and DNA adduct formation of individual C2-C8 1-alkenes was studied in the rat after exposure to 300 ppm (688mg/m3), 12 h a day for 3 consecutive days. The concentrations of the alkenes were measured in blood, lung, brain, liver, kidney and peri-renal fat immediately after each exposure and 12 h after the third exposure. DNA adducts were determined by 32P-postlabeling in liver. Haemoglobin adducts were determined in erythrocytes by GC/MS and GC/MS/MS. Concentrations of 1-alkenes in blood and organs reached a steady-state level after the first 12 h exposure, and the concentrations 12 h after the last exposure were generally low, except in fat. Concentrations of 1-alkenes in blood and the different tissues increased with increasing number of carbon atoms. However, DNA adducts and haemoglobin adducts decreased with increasing number of carbon atoms with the most pronounced decrease being from C2 to C3. The decrease in haemoglobin adducts was more pronounced than DNA adducts. All 1-alkenes caused formation of detectable levels of haemoglobin and DNA adducts, although the levels of haemoglobin adducts after C4-C8 exposure were low. These results also indicate that extrapolation within the homologous series is possible.
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