Registration Dossier
Registration Dossier
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EC number: 212-783-8 | CAS number: 868-85-9
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Non-validated test system.
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- Ashby J, Paton D (1993) The influence of chemical structure|on the extent and sites of carcinogenesis for 522 rodent|carcinogens and 55 different human carcinogen. Mutat Res|286: 3-74 (abstract)
- Title:
- No information
- Author:
- Ashby J, Tennant R (1988) Chemical structure, Salmonella|mutagenicity and extent of carcinogenicity as indicators of|genotoxic carcinogenesis among 222 chemicals tested in|rodents by the U.S: NCI/NTP. Mutat Res 204: 17 - 115
- Title:
- No information
- Author:
- Ashby J, Tennant R (1991) Definitive relationships among|chemical structure, carcinogenicity and mutagenicity for 301|chemicals tested by the U.S. NTP. Mutat Res 257: 229 - 306
- Title:
- No information
- Author:
- Bakale G, McCreary R (1992) Response of the ke test to|NCI/NTP-screened chemicals. II. Genotoxic carcinogens and|non-genotoxic non-carcinogens. Carcinogenesis 13(8): 1437 -|1445
- Title:
- No information
- Author:
- Benigni R (1990) Rodent tumor profiles, Salmonella|mutagenicity and risk assessment. Mutat Res 244: 79 - 91
- Title:
- No information
- Author:
- Gold LS, Slone TH, Stern BR, Bernstein L (1993) Comparison|of target organs of carcinogenicity for mutagenic and|non-mutagenic chemicals. Mutat Res 286: 75 - 100
Materials and methods
- Type of study / information:
- Correlation of structure, mutagenicity and carcinogenicity.
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dimethyl phosphonate
- EC Number:
- 212-783-8
- EC Name:
- Dimethyl phosphonate
- Cas Number:
- 868-85-9
- Molecular formula:
- C2H7O3P
- IUPAC Name:
- dimethyl phosphonate
Constituent 1
Results and discussion
Any other information on results incl. tables
NTP/NCI Carcinogens were clustered. DMP was put in Cluster 2 with clear evidence to induce lung and stomach cancer in male rats. The Ames test result of DMP is positive (50% of Cluster 2 Carcinogens had a positive Ames test result and 50 % a negative result). DMP is classified as a mutagenic substance. DMP is put in Group B: Agents found to be carcinogenic to only a single species but to be active at 2 or more sites in that species.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
