Registration Dossier

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Preliminary test.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1985
Report date:
1985
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1994

Materials and methods

Principles of method if other than guideline:
Method: other: IRT
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
IUPAC Name:
Automatically generated during migration to IUCLID 6, no data available
Details on test material:
Test substance: 15 % N-Methylol methacrylamide in water

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Duration of exposure:
7 h
No. of animals per sex per dose:
6

Results and discussion

Any other information on results incl. tables

Results:

No mortalities after 7 h of exposition in a saturated atmosphere at 20 °C.
During exposure wiping of the snouts and watery nasal secretions were observed. After exposure the secretion from the noses became reddish with a 

positive proof of blood, and this lasted for 1 day. No adverse effects were 

noted during the subsequent 14-day observation period.

Applicant's summary and conclusion