Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Preliminary test.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1985
Report date:
1985
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1994

Materials and methods

Principles of method if other than guideline:
Method: other: IRT
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
IUPAC Name:
Automatically generated during migration to IUCLID 6, no data available
Details on test material:
Test substance: 15 % N-Methylol methacrylamide in water

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Duration of exposure:
7 h
No. of animals per sex per dose:
6

Results and discussion

Any other information on results incl. tables

Results:

No mortalities after 7 h of exposition in a saturated atmosphere at 20 °C.
During exposure wiping of the snouts and watery nasal secretions were observed. After exposure the secretion from the noses became reddish with a 

positive proof of blood, and this lasted for 1 day. No adverse effects were 

noted during the subsequent 14-day observation period.

Applicant's summary and conclusion