Registration Dossier

Administrative data

Endpoint:
dermal absorption
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2012
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: in silico calculation with scientifically accepted method. No experimental result.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report date:
2012

Materials and methods

Principles of method if other than guideline:
The prediction model used in this investigation for
a set of methacrylate chemicals is based on an established model (Potts and Guy,
1992), using data derived with human epidermal membranes.

Test material

Constituent 1
Reference substance name:
N-(hydroxymethyl) methacrylamide
IUPAC Name:
N-(hydroxymethyl) methacrylamide
Constituent 2
Chemical structure
Reference substance name:
N-(hydroxymethyl)methacrylamide
EC Number:
213-086-1
EC Name:
N-(hydroxymethyl)methacrylamide
Cas Number:
923-02-4
Molecular formula:
C5H9NO2
IUPAC Name:
N-(hydroxymethyl)-2-methylacrylamide

Results and discussion

Applicant's summary and conclusion

Conclusions:
In an established prediction model according to the method of Potts and Guy,
(1992), using data derived with human epidermal membranes, the absorption of N-methylol methacrylamide through human skin was predicted to be low. The predicted flux was calculated to be 0.768 µg/cm²/hr
Executive summary:

In an established prediction model according to the method of Potts and Guy,

(1992), using data derived with human epidermal membranes, the absorption of N-methylol methacrylamide through human skin was predicted to be low. The predicted flux was calculated to be 0.768 µg/cm²/hr.