Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2012
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: in silico calculation with scientifically accepted method. No experimental result.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report date:
2012

Materials and methods

Principles of method if other than guideline:
The prediction model used in this investigation for
a set of methacrylate chemicals is based on an established model (Potts and Guy,
1992), using data derived with human epidermal membranes.

Test material

Constituent 1
Reference substance name:
N-(hydroxymethyl) methacrylamide
IUPAC Name:
N-(hydroxymethyl) methacrylamide
Constituent 2
Chemical structure
Reference substance name:
N-(hydroxymethyl)methacrylamide
EC Number:
213-086-1
EC Name:
N-(hydroxymethyl)methacrylamide
Cas Number:
923-02-4
Molecular formula:
C5H9NO2
IUPAC Name:
N-(hydroxymethyl)-2-methylacrylamide

Results and discussion

Applicant's summary and conclusion

Conclusions:
In an established prediction model according to the method of Potts and Guy,
(1992), using data derived with human epidermal membranes, the absorption of N-methylol methacrylamide through human skin was predicted to be low. The predicted flux was calculated to be 0.768 µg/cm²/hr
Executive summary:

In an established prediction model according to the method of Potts and Guy,

(1992), using data derived with human epidermal membranes, the absorption of N-methylol methacrylamide through human skin was predicted to be low. The predicted flux was calculated to be 0.768 µg/cm²/hr.