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Administrative data

Link to relevant study record(s)

Description of key information

Hydrolysis of  N-methyl methacrylamide entering the body does not occur to a major extent as demonstrated in a test with simulants of saliva, gastric fluid and intestinal fluid (details see 5.1.2). Basically, the low log P value and good water solubility indicate the absence of a bioaccumulation potential.
Bioaccumulation as well as the dermal absorption of N-methylol methacrylamide is also expected to be low due to results on structural analogues and QSAR calculations, respectively. Inhalation is not a relevant exposure pathway due to the low vapour pressure and handling as aqueous solution only.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

Hydrolysis of N-methyl methacrylamide entering the body does not occur to a major extent as demonstrated in a test with simulants of saliva, gastric fluid and intestinal fluid (details see 5.1.2)

Basically, the low log P value and good water solubility indicate the absence of a bioaccumulation potential.

In analogy to results on the structural closely related N-methylol acrylamide, rapid renal elimination of N-methylol methacrylamide as such and via glutathione conjugation is expected.

Dermal absorption of N-methylol methacrylamide was predicted to be low by in-silico modelling according to Potts and Guy (1992).

Absortion by inhalation can almost be excluded due to the low vapour pressure of the substance which is handled in aqueous solution only.