Registration Dossier
Registration Dossier
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EC number: 203-475-4 | CAS number: 107-25-5
Endpoint summary
Administrative data
Description of key information
Not irritating to the rabbit skin (cold liquid).
Not irritating to the rabbit eye (cold liquid).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
In a study on skin irritation of MVE (Dow 1990) there was no erythema, edema, or other irritation in any of 6 New Zealand White rabbits one hour and 1, 2, 3, 7, 10, or 14 days after exposure (occlusive for 4 h) to 0.5 mL of undiluted, cold liquid test substance.
The instillation of 0.1 mL undiluted, cold liquid to the eye resulted only in minor transient conjunctival irritation in 5/6 New Zealand White rabbits 24 h after application; the effects were fully reversible within 24 h (Dow 1990).
Justification for classification or non-classification
Classification for skin or eye irritation is not warranted according to the criteria of EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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