Registration Dossier
Registration Dossier
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EC number: 225-172-6 | CAS number: 4698-11-7
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 5.1.2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 10-methoxy-5H-dibenz[b,f]azepine
- EC Number:
- 225-172-6
- EC Name:
- 10-methoxy-5H-dibenz[b,f]azepine
- Cas Number:
- 4698-11-7
- Molecular formula:
- C15H13NO
- IUPAC Name:
- 10-methoxy-5H-dibenzo[b,f]azepine
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 2.9
- Temp.:
- 22.8
- Remarks on result:
- other: pH not indicated
Any other information on results incl. tables
There are 2 minor components with different log Pow:
Minor component 1: log Pow= 1.2
Minor component 2: log Pow = 2.4
From the structural formula of test substance, the log Pow was calculated to be 3.8 using the Rekker calculation method. The results of the calculation method and the HPLC method are not in agreement. Since the HPLC method is a more accurate method than the calculation method, the result of the HPLC method is reported as the partition coefficient.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
