Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Isopropyl chloroformate
EC Number:
203-563-2
EC Name:
Isopropyl chloroformate
Cas Number:
108-23-6
Molecular formula:
C4H7ClO2
IUPAC Name:
propan-2-yl carbonochloridate

Test animals

Species:
rabbit
Strain:
Vienna White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
0.5 g
Duration of treatment / exposure:
3 minutes
1 hour
4 hours
Observation period:
14 days

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24, 48 h
Score:
4
Reversibility:
not fully reversible within: 14 days
Irritant / corrosive response data:
24 h - congested skin with slight edema
48 h - slightly congested and dried skin
14 d - dried skin

Applicant's summary and conclusion

Interpretation of results:
moderately irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU