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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
3 (not reliable)

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
No information
Year:
1970
Bibliographic source:
British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- v. 27, p. 1, 1970 (RTECS Database)
Reference Type:
review article or handbook
Title:
No information
Year:
1992
Bibliographic source:
R.J. Lewis, sr., Sax´s Dangerous Properties of Industrial Materials, Eighth Edition, 1992

Materials and methods

Principles of method if other than guideline:
Database entry, method not known.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Isopropyl chloroformate
EC Number:
203-563-2
EC Name:
Isopropyl chloroformate
Cas Number:
108-23-6
Molecular formula:
C4H7ClO2
IUPAC Name:
propan-2-yl carbonochloridate

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Duration of exposure:
5 h
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LCLo
Effect level:
200 ppm
Based on:
not specified
Exp. duration:
5 h
Clinical signs:
other: Lungs, Thorax, or Respiration: Dyspnea

Applicant's summary and conclusion

Interpretation of results:
highly toxic
Remarks:
Migrated information Criteria used for interpretation of results: EU