Registration Dossier

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
Isopropyl chloroformate
EC Number:
203-563-2
EC Name:
Isopropyl chloroformate
Cas Number:
108-23-6
Molecular formula:
C4H7ClO2
IUPAC Name:
propan-2-yl carbonochloridate

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
0.3163 ml/kg
0.3981 ml/kg
0.5020 ml/kg
0.6310 ml/kg
0.7943 ml/kg
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
468.3 - 632.4 mg/kg bw
Based on:
test mat.
Sex:
male
Dose descriptor:
approximate LD50
Effect level:
544.2 mg/kg bw
Based on:
test mat.
Mortality:
0.3163 ml/kg
0.3981 ml/kg
0.5020 ml/kg
0.6310 ml/kg
0.7943 ml/kg
Body weight:
110-150 g
Gross pathology:
Injury of gastric mucous membrane.

Applicant's summary and conclusion

Interpretation of results:
sligthly toxic
Remarks:
Migrated information Criteria used for interpretation of results: EU