Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1970
Report date:
1970

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standard.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(2-hydroxyethyl)pyrrolidin-2-one
EC Number:
222-359-4
EC Name:
1-(2-hydroxyethyl)pyrrolidin-2-one
Cas Number:
3445-11-2
Molecular formula:
C6H11NO2
IUPAC Name:
1-(2-hydroxyethyl)pyrrolidin-2-one
Details on test material:
Name of the test substance used in the study report: 1-(2-hydroxyethyl)pyrrolidone-2

Test animals

Species:
mouse
Strain:
other: Kisslegg
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Details on exposure:
The test substance was given as a 2, 20 or 30% (v/v) aqueous solution
Doses:
200, 1600, 3200, 4000, 5000, 5600, 6400 mm3/kg bw
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 6 000 other: mm3/kg bw
Based on:
test mat.
Remarks on result:
other: original value
Sex:
male/female
Dose descriptor:
LD50
Effect level:
6 900 mg/kg bw
Based on:
test mat.
Remarks on result:
other: calculated from original value
Mortality:
200, 1600, 3200 and 4000 mm3/kg: no mortalities
5000 mm3/kg: 2/5 female animals after 14 days
5600 mm3/kg: 1/5 males after 14 days
6400 mm3/kg: 3/5 males and 4/5 females after 14 days.
Clinical signs:
Dyspnea, abdominal and lateral positions and convulsions.
Body weight:
No datails given in study report.
Gross pathology:
No abnormalities detected.

Applicant's summary and conclusion