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EC number: 915-687-0
CAS number: 1065336-91-5
The test article is of low toxicity after single ingestion and virtually
non toxic after single skin contact.
Oral: LD50 = 3230 mg/kg bw
Dermal: LD50 = >3000 mg/kg bw (no study available, assessment based on
data from a structurally related compound)
Table 2. Body weights in grams and standard
200 ± 9.1
246 ± 9.9
289 ± 7.6
180 ± 5.3
197 ± 6.7
216 ± 6.6
214 ± 6.7
252 ± 7.3
290 ± 6.9
176 ± 3.8
200 ± 5.2
219 ± 6.0
207 ± 6.7
181 ± 2.9
Acute oral toxicity
Two reliable studies assessing the acute oral toxicity of the test
article are available. In the key study, ten Tif: RAIf (SPF) rats/sex
and dose level were treated with the test substance in PEG 400 at dose
levels of 1000, 2500 and 5000 mg/kg body weight by gavage (Ciba-Geigy,
1981). Within the observation period of 14 days sedation, dyspnoea,
ruffled fur, diarrhoea, and curved body position have been observed,
which were reversible within the observation period. Mortalities
occurred at the high dose and the mid dose level. At necropsy, no
substance-related gross organ changes have been observed. Based on the
results of this study, an LD50 of 3230 (2615 -4247) mg/kg bw was derived.
This finding was supported in a second study conducted with groups of
five Tif: RAIf (SPF) rats per sex (Ciba-Geigy, 1979). The test article
in PEG 400 was administered at dose levels of 100, 200, 3000, 4000, 6000
and 8000 mg/kg body weight. Within the observation period of 14 days
sedation, dyspnoea, ruffled fur and curved body position have been
observed, which were reversible within the observation period.
Mortalities were recorded at dose levels of 3000 mg/kg and higher. No
substance related gross organ changes were seen. Based on the results of
this study, an LD50 of 3125 (2369-3920) mg/kg bodyweight was determined.
Acute dermal toxicity
No study is available. Assessment is based on a study performed with a
structurally related compound (see attached read across justification).
In this acute dermal toxicity study, three New Zealand White rabbits per
sex were given a single dermal dose of the test substance at dose levels
of 2150 and 3170 mg/kg body weight. The test compound was applied
occlusively and held in place for 24 hours followed by an observation
period of 14 days. No deaths occurred. Based on the results of this
study, a dermal LD50 of >3170 mg/kg bw was derived.
Acute inhalation toxicity
No data available
Classification, Labeling, and Packaging Regulation (EC) No.
The available experimental test data are reliable and suitable for the
purpose of classification under Regulation (EC) No.1272/2008. Based on
the present data, classification for acute toxicity is not warranted
under Regulation (EC) No.1272/2008.
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