Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1976
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1976

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not applicable
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
other: OFA
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
1701, 2551, 3401, 4252 mg/kg nicofluoromethanol

No. of animals per sex per dose:
10
Control animals:
yes

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
LD50
Effect level:
ca. 2 667 mg/kg bw
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 2 979 mg/kg bw
Mortality:
Mortality observed in male at 2551mg/kg (1/10), 3401mg/kg (8/10) and 4252mg/kg (10/10)
Mortality observed in female at 2551mg/kg (3/10), 3401mg/kg (10/10) and 4252mg/kg (10/10)

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information not toxic Criteria used for interpretation of results: EU