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EC number: 202-445-8 | CAS number: 95-73-8
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzene, 2,4-dichloro-1-methyl-
- IUPAC Name:
- Benzene, 2,4-dichloro-1-methyl-
- Reference substance name:
- 2,4-dichlorotoluene
- EC Number:
- 202-445-8
- EC Name:
- 2,4-dichlorotoluene
- Cas Number:
- 95-73-8
- Molecular formula:
- C7H6Cl2
- IUPAC Name:
- 2,4-dichloro-1-methylbenzene
Constituent 1
Constituent 2
Test organisms
- Test organisms (species):
- Daphnia magna
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 19 mg/L
- Basis for effect:
- mortality
- Duration:
- 21 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 2 mg/L
- Basis for effect:
- mortality
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- > 2 mg/L
- Basis for effect:
- other: reproduction
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 2 mg/L
Applicant's summary and conclusion
- Conclusions:
- The following values are determined for 2,4-dichlorotoluene:
LC50 (24h): 19 mg/L (basis mortality),
LC50 (21d): > 2.0 mg/L (basis mortality),
EC50 (21d): > 2.0 mg/L (basis reproduction),
NOEC (21d): 2.0 mg/L. - Executive summary:
At concentrations above 6.2 mg/l of 2,4-dichlorotoluene 100 % of the parental daphnia died.
In the lower concentrations the mortalities of parental daphnia were as high as in the control group (5/40).
As a result the LC50 (21d) was > 2.0 mg/l (less than 6.2 mg/l).
The average number of offspring produced per adults for 21 days was reported to be 29.6, 27.6 and 23.2 individuals at the concentrations of 0.2, 0.62 and 2.0 mg/l, respectively.
These result showed that the dose-response relationship was obscure and thus the 21d EC50 on reproduction was regarded to be > 2.0 mg/l, however all daphnia at the concentration above (6.2 mg/l) died.
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