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EC number: 225-306-3 | CAS number: 4767-03-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Genetic toxicity in vitro
Bacterial reverse mutation test
The potential of Bis-MPA (2,2 -dimethylol propionic acid) to cause genetic damage was evaluated in a GLP study conducted according to OECD TG 471 (van Delft, 1998). Salmonella typhimurium strains TA1535, TA1537, TA98 and TA100 were tested both in the presence and absence of metabolic activation. There was no evidence of toxicity or mutagenicity up to concentrations of 5000 µg/plate. Therefore it was concluded that Bis-MPA was not mutagenic under the conditions of the study.
In a second GLP study according to OECD Guideline 471 (RTC, 2015) Bis-MPA was examined for the ability to induce gene mutations in Escherichia coli strain WP2 uvrA. It is concluded that Bis-MPA did not induce reverse mutation in Escherichia coli in the absence or presence of S9 metabolism, under the reported experimental conditions.
Mammalian cell gene mutation test
A GLP gene mutation study was performed with Bis-MPA (2,2 -dimethylol propionic acid), according to OECD TG 476 (van Delft, 1998). The potential of the test substance to induce mutations at the TK-locus of L5178Y cells was determined, both in the presence and absence of metabolic activation. Bis-MPA was not found to be cytotoxic or genotoxic, either in the presence or absence of metabolic activation, tested up to a concentration of 10 mM.
Mammalian chromosome aberration test
A GLP chromosome aberration study was performed with Bis-MPA (2,2 -dimethylol propionic acid), according to OECD TG 473 (van Delft, 1998). The study was carried out with Chinese hamster ovary cells, in the presence and absence of metabolic activation, up to a concentration of 1250 µg/ml. Under the conditions of the study, Bis-MPA was found to be non-clastogenic.
Justification for selection of genetic toxicity endpoint
A weight of evidence approach is taken for this endpoint: no key study is identified. Three in vitro studies of genotoxicity are available, all studies report negative results.
Short description of key information:
Bis-MPA (dimethylol propionic acid) was not mutagenic or clastogenic when tested in vitro in a bacterial reverse mutation assay, a mammalian cell gene mutation assay, and a mammalian chromosome aberration test.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Dimethylolpropionic acid was not mutagenic or clastogenic when tested in vitro in a bacterial reverse mutation assay, a mammalian cell gene mutation assay, and a mammalian chromosome aberration test. Classification according to DSD or to Regulation (EC) No 1272/2008 is therefore not required.
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