Registration Dossier
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EC number: 225-306-3 | CAS number: 4767-03-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
Dimethylolpropionic acid is likely to be rapidly and extensively absorbed following oral and dermal exposure, with absorption following dermal exposure likely to be less extensive and more prolonged. Extensive distribution in body fluids is predicted. Dimethylolpropionic acid is likely to be metabolised by sequential oxidation of the hydroxy groups and excreted rapidly in the urine.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
No data are available, however it can be predicted that Bis-MPA (dimethylolpropionic acid) will be rapidly and extensively absorbed following oral and dermal exposure, with absorption following dermal exposure likely to be less extensive and more prolonged. Extensive distribution in body fluids is predicted. Bis-MPA is likely to be metabolised by sequential oxidation of the hydroxy groups and excreted rapidly in the urine. Rapid renal excretion is likely and no bioaccumulation is predicted.
An adequate assessment of the basic toxicokinetics of Dimethylolpropionic acid can be made from the exisiting toxicity data and theoretical considerations, without the need for specific testing.
Absorption
Extensive oral absorption of Dimethylolpropionic acid is predicted based on its molecular size, solubility, chemical structure and on the basis of experience with other alcohols. The Dimethylolpropionic acid molecule addtionally satisifies Lipinski's rule of 5 (OECD QSAR Toolbox). Oral absorption is demonstrated by the findings of the acute oral toxicity study and systemic effects in the 90-day oral study. Absorption following inhalation exposure is also likely to be extensive. although significant inhalation exposure is not predicted. Dermal absorption is likely to be less extensive than oral absorption, but is likely to occur to some extent. The results of the acute dermal toxicity study support this theory.
Distribution
No data are available, however rapid and extensive distribition can be predicted based on the knowledge of other alcohols.
Metabolism
Sequential oxidative metabolism of the hydroxy groups is predicted, based on known metabolic reactions and the elucidated pathways for other alcohol compounds.
Excretion
Rapid and extensive renal excretion of Dimethylolpropionic acid and its metabolites is likely, with no potential for bioaccumulation based on chemical properties and also on the low toxicity seen in the 90-day study.
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