2,2-bis(hydroxymethyl)propionic acid

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2009-03-30

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Qualifier:

no guideline followed

Principles of method if other than guideline:

The particle size distribution was analysed by laser diffraction using the instrument Malvern Mastersizer X. Xylene was poured into the dispersing unit, and pumped through the system. It was made sure that no air bubbles were present. A concentrated slurry of the sample in dispersant was made in a beaker by vigorous stirring. Alignment was performed and the background was measured. The sample was added from the slurry into the dispersing unit with a cut-off plastic Pasteur pipette. The sample was adjusted until an acceptable obscuration (15-25%) of the laser beam was obtained.
The dispersion was homogenized after 5 minutes and the particle size distribution was measured.

GLP compliance:

no

Type of method:

Laser scattering/diffraction

Remarks:

Instrument: Malvern MastersizerX, Instrument A 2043 Lens: 300 mm Beam length: 2.4 mm Obscuration: 20.8 %

Type of particle tested:

other: Slurry of the sample in Xylene as dispersant, prepared by vigorous stirring in a beaker

Type of distribution:

volumetric distribution

Specific details on test material used for the study:

- Analytical purity: > 98% GC purity
- Lot/batch No.: 581017
- Storage condition of test material: room temperature

Percentile:

D90

Mean:

135.17 µm

St. dev.:

0

Remarks on result:

other: No standard deviation was determined

Key result

Percentile:

D50

Mean:

66.09 µm

St. dev.:

0

Remarks on result:

other: No standard deviation was determined

Percentile:

D10

Mean:

12.8 µm

St. dev.:

0

Remarks on result:

other: No standard deviation was determined

No.:

#1

Size:

< 10 µm

Distribution:

6.9 %

No.:

#2

Size:

< 50 µm

Distribution:

37.3 %

No.:

#3

Size:

< 100 µm

Distribution:

75.4 %

Conclusions:

In an experimental study using the laser diffraction method, > 75 % of Bis-MPA particles were determined to have a diameter of less then 100 µm. The D50 is at 66 µm.

Executive summary:

In an experimental study using the laser diffraction method, > 75 % of Bis-MPA particles were determined to have a diameter of less then 100 µm.

The D₅₀ percentile ist a 66 µm.

Description of key information

In an experimental study using the laser diffraction method, > 75 % of Bis-MPA particles were determined to have a diameter of less then 100 µm.

The D₅₀ percentile ist a 66 µm.