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EC number: 292-562-0 | CAS number: 90640-43-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because a pre-natal developmental toxicity study is available
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
No studies are available on N-C12,14 alkyl-1,3-diaminopropane (CAS 90640-43-0), also referred to as C12-14-diamine.
Cross-reading to data available on other diamines and polyamines is acceptable on the basis of identical alkyl-diamine structure, resulting to the same functional groups with similar properties leading to common biological activity, and common metabolic degradation. Further information on the applicability of the read-across from various diamines to Coco-diamine can be obtained from the document "Category polyamines - 20170518.pdf" added to IUCLID Ch. 13.
No adverse effects on reproductive organs were identified in the 90 day study in rats on C12-14-diamine. This study was performed according to OECD 408 and does not include detailed reproductive parameters as indicated in OECD 416. Nevertheless, the 90 day study did not indicate any effects on weight of testes, prostate, seminal vesicles, ovaries, and uterus. Histological examination of these tissues also confirmed no treatment-related effects. There was a very slight increase in relative weight of the epididymis in the high dose animals but there were no corresponding histological changes. There was also no indication of a dose-response relationship. Accordingly, the effect on epididymis is not believed to be treatment related.
Additional data is available from a developmental toxicity study performed on Oleyl-diamine, which also included endpoints relevant to assessing an effect on fertility. No effects on pre/post implantation rate, late/early resorptions, corpora lutea or number of live fetuses were seen in this study. Although the available data on Oleyl-diamine does not include information on sperm parameters and oestrus cycle, it supports the conclusion that there are no indications of an effect of diamines on fertility.
On overall, there are various reproduction screening studies, a full 2-generation study and various developmental toxicity studies available, covering the range of Polyamines, which show a clear lack for concern for reproduction toxicity.
In addition, there is no consumer exposure to C12-14-diamine. Further, manufacture and use are highly controlled. Its use is limited to industrial and professional users where following its severe corrosive properties the applied protection measures will provide for sufficient protection to prevent exposure
Data source
Materials and methods
Results and discussion
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
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