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Toxicity to microorganisms

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Description of key information

The 3 h EC50 of is 20.5 mg/L determined in respiration inhibition test (OECD TG 209) .

Key value for chemical safety assessment

EC50 for microorganisms:
20.5 mg/L

Additional information

Three toxicity studies with micro-organisms are available with reliability 1,2 and 3. The lowest toxicity value within this category was observed in the study conducted with N-C12-14-alkyltrimethylenediamines (CAS No. 90640-43-0) (Noack, 2008, reliability 1). This study is selected as key study.

This respiration Inhibition Test with activated sludge was performed with the test item N-C12 -14 -alkyltrimethylenediamines (CAS No. 90640 -43 -0) according to OECD TG 209 (Noack, 2008). The test system used activated sludge of the municipal treatment plant of D-31157 Sarstedt. The test was performed under static conditions with nominal concentrations in the range of 3.2 - 100 mg/L. The respiration rates of control, reference and test item concentrations were measured after a contact time of three hours, and the inhibitory effects of the test and reference concentrations were determined in comparison to the control respiration rates. The inhibition ranged from -5 to 95 %. The EC50 was 20.5 mg/L (C.I. 95% 18.4 -22.5) calculated via sigmoidal dose-response analysis.