Registration Dossier

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient documentation, Klimisch 4.e study.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979

Materials and methods

Principles of method if other than guideline:
The authors tested the eye irritation potential of benzoyl chloride by placing into the conjunctival sac of one eye 100 µL of the test substance of each rabbit. They followed the eye damages and signs of irritations.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): benzoyl chlorid
- Physical state: liquid
- Analytical purity: 99-100 %ig
- Lot/batch No.: 024042-20
- other:
Substance number: 027707-02
No further data available

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
- Source: Hacking & Churchill, huntingdon, England
- Weight at study initiation: 3-4 kg
- Housing: in standard cages
- Diet (e.g. ad libitum): Z 222 food from Höing Verden/Aller) ad libitum
- Water (e.g. ad libitum): ad libitum

No further data available

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
100 µL
Duration of treatment / exposure:
once
Observation period (in vivo):
Seven days
Number of animals or in vitro replicates:
Two
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no washing

SCORING SYSTEM: unknown


TOOL USED TO ASSESS SCORE: unknwon
No further data available

Results and discussion

In vivo

Irritant / corrosive response data:
Conjunctiva: severe redness, moderate to severe chemosis up to the end of the observation period;
Iris: slight to moderate swollen and hyperemic;
Cornea: slight diffuse opacity
No further data
Other effects:
Strong lacrimation was observed throughout the overall duration of the observation period.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
In the test conditions, the authors estimated the eye irritation potential of benzoyl chloride by exposing the conjonctival sac of rabbits eyes to 0.1 mL of the test substance. They estimated the substance was a strong irritant and corrosivefor the cornea after seven days of observation.
Executive summary:

The authors estimated the eye irritation potential of benzoyl chloride by exposing conjonctival sac of New Zealand rabbits eyes to 0.1 mL of benzoyl chloride (CAS n° 98 -88 -4). They recorded eye damages and signs of irritation within a seven days post exposure observation period. Neither a scoring system is reported, nor criteria for interpretation of results.

By the end of the observation period, severe redness and moderate to severe chemosis of the conjonctivae, a slight to moderate swollen and hyperemic iris and a slight diffuse opacity of the cornea were observed . No scores are available for any of the parameters.

They concluded that benzoyl chloride is a strong irritant for eyes and corrosive for the cornea.

The GLP status of this study is unknwon as most of the details on materials and details. Results are insufficiently described as no scores are available, and neither a scoring system, nor criteria for interpretation of results are reported. Therefore, this study should be considered as not assignable due to insufficient documentation, a Klimisch 4.e study.