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Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Negligibly low 

Key value for chemical safety assessment

Additional information

The relevant part of the submission item Guanidine carbonate is the Guanidine (CAS 113-00-8) as discussed in the section on Environmental fate and pathways above. It is present as the Guanidinium kation (see section Dissociation constant). The carbonate is considered negligible for the environmental assessment and disregarded in the following discussion. Guanidine has a pKa of 12.5 (Budaravi 1996). This value indicates that it will exist almost entirely as the Guanidine kation at environmental pH. Volatilization from moist soil and water surfaces is not an important environmental fate process since kations do not volatilize (HSDB 2008). The potential of Guanidine to volatilize from dry soil surfaces, where it would be in the neutral from exists based upon an estimated vapour pressure determined from a fragment constant method (Lyman 1985), which is estimated to be 2.2 mm Hg at 25 °C (HSDB 2008 using US EPA 2007 EPI Suite). This value corresponds to 293 Pa (conversion factor 133.3224). Nonetheless volatilisation is deemed negligible as Guanidine is fast degraded in soils.

  • Budaravi S ed (1996). The Merck Index. An Encyclopedia of Chemicals, Drugs, and Biologicals, 12th edition. ISBN 0911910-12-3 New York, NJ, U.S.A., Merck
  • Lyman WJ (1985) p. 31 In Environmental Exposure From Chemicals Vol I, Neely WB, Blau GE, eds, Boca Raton, FL, U.S.A.CRC Press
  • HSDB Hazardous Substances Databank (2008). GUANIDINE, CASRN: 113-00-8, Number: 7603. Last Revision Date: 2008-08 -26, Last Review Date: Reviewed by SRP 5/8/2008, Update History: Complete Update on 2008 -08-26, 38 fields added/edited/deleted, Created 20071213
  • US EPA United States Environmental Protection Agency (2007). Estimation Program Interface (EPI) Suite. Ver.3.20. February, 2007. Available from, as of Dec 17, 2007: