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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Description of key information

Not bioaccumulative

Key value for chemical safety assessment

BCF (aquatic species):
0.1 L/kg ww

Additional information

Testing for this for this endpoint has been waived in accordance with column 2 restrictions. The relevant part of the submission item Guanidine carbonate is the Guanidine (CAS 113-00-8) as discussed in the section on Environmental fate and pathways above. It is present as the Guanidinium kation (see section Dissociation constant). The carbonate, is considered negligible for the environmental assessment and disregarded in the following discussion.

Data on bioaccumulation exist from Guanidine (CAS 113-00-8), which were published by NITE (1997). BCF values of <0.1 to 0.1 were measured for carp (Cyprinus carpio) exposed to 2 and 20 µg/L of Guanidine over a 6 week incubation period (NITE 1997). According to a classification scheme (Franke 1994), these BCF values suggest bioconcentration in aquatic organisms is low (HSBD 2008).

  • Franke C, Studinger G, Berger G, Böhling S, Bruckmann U, Cohors-Fresenborg D, Jöhncke U (1994) The assessment of bioaccumulation. DOI: 10.1016/0045-6535(94)90281-X ISSN: 0045-6535 Chemosphere 29(7):1501-14
  • HSDB Hazardous Substances Databank (2008). GUANIDINE, CASRN: 113-00-8, Number: 7603. Last Revision Date: 2008-08 -26, Last Review Date: Reviewed by SRP 5/8/2008, Update History: Complete Update on 2008 -08-26, 38 fields added/edited/deleted, Created 20071213
  • NITE National Institute of Technology and Evaluation (1997). Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law. Information on the chemical published in the Official Bulletin of Economy, Trade and Industry. Published Date: 1997/12/26. Published Chemical Name: Guanidine [Class-Reference No. : 2-1773]. Chemicals Inspection and Testing Institute. Japan Chemical Industry Ecology - Toxicology and Information Center. Available at: http://www.safe.nite.go.jp/english/kizon/KIZON_start_hazkizon.html as of November 11, 2011.

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