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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Federal Register 38, No 187, §1500.42, p27019, 27 Sept 1973
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide
EC Number:
278-355-8
EC Name:
Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide
Cas Number:
75980-60-8
Molecular formula:
C22H21O2P
IUPAC Name:
(mesitylcarbonyl)(diphenyl)phosphine oxide
Details on test material:
- Name of test material (as cited in study report): Initiator 554
- Analytical purity: >98%
- Physical state: crystalline
- Storage condition of test material: protected from light

Test animals / tissue source

Species:
rabbit
Strain:
Vienna White
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
- Source: Gaukler
- Age at study initiation: not reported
- Weight at study initiation: mean 2.60 kg for male, 2.94 for female
- Diet: Ssniff from the company INTERMAST, ad libitum
- Water: ad libitum

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: untreated left eye of the same animal
Amount / concentration applied:
TEST MATERIAL
Amount applied: 56 mg (corresponding to 0.1 ml bulk volume)
Duration of treatment / exposure:
test substance was not washed
Observation period (in vivo):
5 days
(observations after 24, 48, 72h, 5d)
Number of animals or in vitro replicates:
4 females and 2 males
Details on study design:
SCORING SYSTEM: Draize

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Remarks:
of all test animals
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
iris score
Basis:
mean
Remarks:
of all test animals
Time point:
24/48/72 h
Score:
0
Max. score:
2
Irritation parameter:
conjunctivae score
Basis:
mean
Remarks:
animals #1,3,5,6
Time point:
24/48/72 h
Score:
0.3
Max. score:
3
Reversibility:
fully reversible within: 48h
Remarks on result:
other: redness score was 2 in all test animals after 1 h
Irritation parameter:
conjunctivae score
Basis:
mean
Remarks:
animals #2,4
Time point:
24/48/72 h
Score:
>= 0.6 - <= 1
Max. score:
3
Reversibility:
fully reversible within: 72h
Remarks on result:
other: redness score was 2 in all test animals after 1 h
Irritation parameter:
chemosis score
Basis:
mean
Remarks:
of all test animals
Time point:
24/48/72 h
Score:
0
Max. score:
4
Remarks on result:
other: chemosis score was 1 in all test animals after 1 h
Irritation parameter:
other: conjunctiva discharge
Basis:
mean
Remarks:
all test animals
Time point:
24/48/72 h
Score:
0
Max. score:
3
Remarks on result:
other: conjunctiva discharge score was 2 in all test animals after 1 h

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information