Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Sanders (2010) was performed in line with appropriate guidelines and to GLP using dibromomethane as the test material. The Local Lymph Node Assay demonstrated that dibromomethane is not a skin sensitiser. The fully justifiable read-across between the test material and 1,2-dibromoethane indicates that 1,2-dibromoethane can also be consiered to be a non skin sensitiser.


Migrated from Short description of key information:
Sanders (2010) was performed to comply with OECD 429 and OPPTS 870.2600 testing conditions under GLP conditions and using dibromomethane as the test material.

Justification for read-across
1,2-dibromoethane (BrCH2CH2Br) and dibromomethane (CH2Br2) are considered 'similar' substances. Both belong to the same chemical group of 'halogenated alkanes' and both are expected to bind with proteins by the same mechanism. The 'analogue approach' was used for the prediction of skin sensitisation of 1,2-dibromoethane and dibromomethane by OECD QSAR toolbox v.2. The program selected for both substances the same analogues for comparison (1,2-dichloropropane, 1,2,3-trichloropropane and chloroethane). The results of the prediction indicate that sensitisation of both substances is 'ambiguous'. Based on the above it can be concluded that read-across for the skin sensitisation endpoint from the study for dibromomethane to 1,2-dibromoethane is acceptable and can be performed.

Respiratory sensitisation

Endpoint conclusion
Additional information:
Migrated from Short description of key information:
No data available.

Justification for classification or non-classification

The data indicate that 1,2 -dibromoethane does not need to be classified as a skin sensitiser under the Dangerous Substances Directive or GHS.