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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
not reported.
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study conducted in accordance with generally accepted scientific principles, possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of the relevant results.

Data source

Reference
Reference Type:
publication
Title:
Inhalation Toxicity of Fumigant Mixtures: Individual and Joint Effects of Ethylene Dichloride, Carbon Tetrachloride, and Ethylene Dibromide.
Author:
McCollister, D.D., Hollingsworth, R.L., Oyen, F. & Rowe, V.K.
Year:
1956
Bibliographic source:
A.M.A. Archives of Industrial Health, Vol. 13, pp. 1-7.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
Principles of method if other than guideline:
No data on deviations from the test guideline was reported in the text.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
The samples used in the experimental studies were obtained from commercial stock ready for distribution and were checked by infrared absorption to be certain that they were representative.

Test animals

Species:
rat
Strain:
other: Albino (not otherwise specified).
Sex:
male/female
Details on test animals and environmental conditions:
No Data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
No data
Doses:
6 doses were used however these were not stated in the paper.
No. of animals per sex per dose:
100 rats (males and females) were used in total.
Control animals:
not specified
Details on study design:
No data
Each of the fumigant mixtures and each individual component were administered in single oral doses to groups of male and female rats by stomach tube as a suspension in corn oil using small amounts of acacia. The number of rats used, the number of dosage levels, and the results of LD50 calculations for each material are given in Table 5.
Statistics:
No data

Results and discussion

Preliminary study:
not applicable.
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
140 mg/kg bw
Based on:
test mat.
95% CL:
120 - 160
Mortality:
It is apparent from the data in Table 5 that carbon tetrachloride is the least toxic and that ethylene dibromide is the most toxic material. Ethylene dichloride and Mixtures 75 and EB-5 have almost identical acute oral LD50 values. Mixture EB-15 shows an intermediate oral toxicity between ethylene dibromide and the other mixtures, as would be predicted. However, for each mixture the "observed" LD50 is greater than that "expected" by calculation.
Clinical signs:
not reported.
Body weight:
not reported.
Gross pathology:
not reported.
Other findings:
not reported.

Any other information on results incl. tables

The LD50 for ethylene dibromide when administered orally to rats was determined to be 140 mg/kg.

Applicant's summary and conclusion

Interpretation of results:
toxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 for ethylene dibromide when administered orally to rats was determined to be 140 mg/kg.