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Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

The key study selected for this endpoint was Ágh, 2010. This study was selected based upon the reliability (allocated a reliability score of 1 based upon the criteria of Klimisch et al, 1997) and as it was the most recent study available. The study was conducted in accordance with the OECD 203 guideline and under GLP conditions. It was performed on Oncorhychus mykiss at nominal concentrations of 20, 11.8, 6.9, 4.1, 2.4 & 1.4 mg/l over a 96 hour exposure period. The study reported a 96 hour LC50 of 1.13mg/l based upon mortality and a 96 hour LC100 of 1.46 mg/l based upon mortality.
All supporting studies were conducted in a similar manner to OECD 203. Holcombe et al, 1995, reports a results of 96h-LC50 32.1 mg/l for Japanese killifish (Oryzias latipes). Landau & Tucker, 1984, reported a result of 48-h LC50 6.2 mg/l for Snook and 48-h LC50 4.8 mg/l for Minnow. Davis and Hardcastle, 1959, reported results of 48-h TLm 18 ppm for Sunfish and 48-h TLm 15 ppm for Bass in the Bayou DeSiard River.

Key value for chemical safety assessment

LC50 for freshwater fish:
1.13 mg/L

Additional information

The key study was conducted in accordance with the OECD 203 guideline under GLP conditions and used the prefered test species (Oncorhychus mykiss) and the prefered exposure duration (96 hours). Based upon this the study was awarded a reliability score of 1 according to the criteria of Klimisch et al, 1997, and as the it was the most recent information available was chosen as the key study. No deviations from the test guideline were reported in the study and reporting of methodology and results was considered to be satisfactory to allow for a comparison with other substances.

All supporting studies conducted on fish were conducted in a similar manner to OECD 203 and were therefore considered of sufficient reliability for consideration in support of the key study.