Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-702-2 | CAS number: 147-85-3
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The LC50 was estimated by QSAR prediction based on trend analysis. The LC50 for short-term fish toxicity (96h) of L-proline was calculated to be 10500 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 10 500 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 10 500 mg/L
Additional information
Results from a feeding study demonstrate that L-proline at a concentration of at least 0.5 % in diet does not have lethal effects to Anguilla japonica when being fed for at least 40 days.
No toxicity at the limit concentration was observed in acute toxicity studies with daphnia (according to OECD202) and algae (according to OECD201) indicating that the substance has a very low / no hazard potential for aquatic organisms. Further, as the substance (in protein) is a basic component of fish food it is very unlikely that fish in an OECD203 study exposed to limit concentrations (100 mg/l) of L-proline show any adverse effect. Therefore and for animal welfare reasons is seems sufficient to use an in silico approach to predict the LC50 for short-term fish toxicity (96h).
An estimation by QSAR based on trend analysis results in a LC50 (96h) of L-proline of 10500 mg/L
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
