Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 270-674-0
CAS number: 68476-32-4
Heavy Fuel Oil Components are no more than moderately irritating to skin under occlusive dressing post 24-hours exposure (insufficient for classification), and non-irritating to the eye.
The dermal irritation potential of Heavy
Fuel Oil Components toward intact and abraded skin has been investigated
in a large number of studies using open or occluded skin contact and
exposure periods of 4 h or 24 h duration. In all instances dermal
responses (erythema, oedema, dryness, cracking etc) were recorded using
a key dermal irritation study (API, 1980b), 0.5 mL of the test material
was applied to the clipped skin of New Zealand White rabbits (3/sex) for
24 hours. The test material was applied to both abraded and non-abraded
skin areas and covered with a closed patch (occlusive dressing). The
animals were monitored over 72 hours post exposure and scored according
to the Draize scale. Significant skin irritation was not observed
Data from multiple supporting studies (ARCO,
1992o-s; 1990d,e; 1989d-f; 1987f; 1986d,e; Mobil, 1992c; 1988f-h; and
API, 1980a,c,d) indicate a variable capacity to elicit skin irritation
with no consistent difference in the relative intensity or relative
persistence of skin reactions following 4 or 24 h contact, or exposure
under occluded or open conditions. Hence although the conditions used in
the majority of studies deviate from those of guideline recommendations,
findings of erythema and oedema scores less than 2 in a majority of
cases indicates that Heavy Fuel Oil Components are no more than
moderately irritating to skin.
Information on the eye irritation potential
of Heavy Fuel Oil Components is available from a large number of
GLP-compliant studies that followed guideline recommendations. In all
instances, neat test substance (0.1 mL) was instilled into the eye of
3-6 rabbits, the eyelids held shut for a few seconds before releasing,
and ocular responses recorded using Draize criteria.
a key eye irritation study (API, 1980b), six New Zealand White rabbits
were treated with 0.1 mL of No 6 heavy fuel oil. An additional three
animals were also treated with 0.1 mL of test substance, following which
their eyes were rinsed with water. Effects on the eyes were monitored
over 7 days with scoring according to the Draize scale. Corneal
opacities of grade 1 and area 1 were seen in some animals at the 24 and
48-hour reading. No iridial inflammation was seen in any of the test
animals. Conjunctival irritation was seen in all of the rabbits at 24
and 48 hours post dosing. All rabbits were negative for irritation after
7 days. The test substance was therefore considered to be mildly
Data from multiple supporting studies (ARCO,
1992t,u; 1991a-c; 1990f,g; 1989g-i; 1988a; 1986f,g; Mobil, 1992d;
1988i-k; and API 1982a; 1980a,c,d) indicate no more than mild or
mild-moderate reversible irritation (mean intensity less than 2) of the
rabbit eye, reflecting redness or swelling (chemosis) of the
conjunctivae with mild corneal opacity or discharge occurring rarely.
Overall, Heavy Fuel Oil Components appear to cause no more than
transient, fully reversible eye irritation.
Justification for selection of skin irritation / corrosion endpoint:
One of 21 available studies.
Justification for selection of eye irritation endpoint:
One of 22 available studies.
The dermal irritation potential of samples
of Heavy Fuel Oil Components has been tested in a large number of
generally GLP-compliant rabbit skin irritation studies. The majority of
data were derived using a 24 hr occluded exposure protocol. The
conclusions of these studies indicate a potential to evoke no more than
moderate skin irritation, with no evidence of injuries in depth
(corrosion). The eye irritation potential of samples of Heavy Fuel Oil
Components has been tested in a number of generally GLP-compliant
near-guideline rabbit eye irritation studies. None of the samples tested
elicited more than transient, fully reversible eye irritation. No
classification is required under the EU
CLP Regulation (EC No. 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again