Registration Dossier

Physical & Chemical properties

Partition coefficient

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Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2007-03-05 to 2007-03-07
Reliability:
1 (reliable without restriction)
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report date:
2007

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Version / remarks:
92/69/EC
Deviations:
no
Principles of method if other than guideline:
NA
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Details on test material:
Batch no: EZ06-B001;

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficientopen allclose all
Type:
log Pow
Partition coefficient:
2.47
Temp.:
20 °C
Type:
Pow
Partition coefficient:
297
Temp.:
20 °C
Details on results:
NA

Any other information on results incl. tables

NA

Applicant's summary and conclusion

Conclusions:
The determined partition coefficient (Pow) for AVE 5530 EVA-KET is 297 ± 3.3 (95 %).
Executive summary:

The determined partition coefficient (Pow) for AVE 5530 EVA-KET is 297 ± 3.3 (95 %) with a log Pow of 2.47.