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Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Principles of method if other than guideline:
Organisation for Economic Co-operation and Development
(OECD), OECD Guidelines for Testing of Chemicals, Section 4,
Health Effects, No. 402, "Acute Dermal Toxicity", Paris
Cedex, 1987.


European Community (EC), Council Directive 67/548/EEC, Annex
V, Part B, Methods for the determination of Toxicity, as
last amended by Commission Directive 92/69/EEC, B.3: "Acute
Toxicity-Dermal". Official Journal of the European
Communities No. L 383, 1992.


United States Environmental Protection Agency (EPA). Health
Effects Test Guidelines, OPPTS 870.1200, Acute Dermal
Toxicity. Office of Prevention, Pesticides and Toxic
Substances (7101), EPA 712-C-96-192, June 1996.


Japanese Ministry of Agriculture, Forestry and Fisheries
(JMAFF), 12 Nousan, Notification No 8147, November 2000,
including the most recent partial revisions.
GLP compliance:
yes
Limit test:
yes

Test animals

Species:
other: Rat, Wistar strain Crl:(WI) BR

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: Corn oil (specific gravity 0.92).
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
Chromodacryorrhoea, ptosis and hunched posture were noted in
the majority of animals. The animals had recovered from the
symptoms between days 2 and 4.
Gross pathology:
Effects on organs:
No abnormalities were found at macroscopic post mortem
examination of the animals.
Other findings:
Signs of toxicity (local):
Scales and scabs were seen in the treated skin-area of one
female during the observation period.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU