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EC number: 246-625-4 | CAS number: 25111-05-1
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily biodegradable: 76.3 - 79.9% after 28 d (OECD 301B, CO2 evolution), 86% after 28 d (OECD 301F, O2 consumption), read across
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Since no studies investigating the ready biodegradability of 2-ethyl-2-(hydroxymethyl)-1,3-propanediyl dioleate (CAS 25111-05-1) are available for this endpoint, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substances Fatty acids, C16-18 even numbered and C18-unsatd. triesters with propylidynetrimethanol (former CAS 57675-44-2), Fatty acids, C16-18 (even numbered) and C16-18-unsatd. (even numbered), triesters with trimethylolpropane (CAS 68002-79-9) and Fatty acids, C8-10 (even), C14-18 (even) and C16-18 (even)-unsatd., triesters with trimethylolpropane (former CAS 85186-89-6) was conducted.
The read-across substances are representative to evaluate the biodegradation of 2-ethyl-2-(hydroxymethyl)-1,3-propanediyl dioleate. 2-ethyl-2-(hydroxymethyl)-1,3-propanediyl dioleate is characterized by C18 unsaturated fatty acid esterified trimethylolpropane (TMP) (mainly di- and triester). The selected source substances are structurally very similar to the target substance and are thus adequate for the assessment of biodegradability of the target substance. Fatty acids, C16-18 even numbered and C18-unsatd. triesters with propylidynetrimethanol (former CAS 57675-44-2) is characterized by C18, C18 unsatd fatty acids triesterified with TMP. Fatty acids, C16-18 (even numbered) and C16-18-unsatd. (even numbered), triesters with trimethylolpropane (CAS 68002-79-9) and Fatty acids, C8-10 (even), C14-18 (even) and C16-18 (even)-unsatd., triesters with trimethylolpropane (former CAS 85186-89-6) mainly consist of C18:1 FA triesterified with TMP. A detailed analogue approach justification is provided in the technical dossier (see IUCLID Section 13).
Two studies, investigating the ready biodegradability of the source substance fatty acids, C16-18 even numbered and C18-unsatd. triesters with propylidynetrimethanol (former CAS 57675-44-2) according to OECD 301B (CO2 Evolution Test), are available. In the first study domestic activated sludge (non-adapted) was used as inoculum (GLP; Häner, 2007) whereas secondary effluent was used in the second study (GLP; King, 1994). Häner (2007) observed a mean degradation of 80% fulfilling the 10-day window. The result from the second study is in the same range resulting in a biodegradation of 76% after 28 d with fulfilment of the 10-d window. Therefore, the source substance can be regarded as readily biodegradable according to OECD criteria.
One study, investigating the ready biodegradability of the source substance fatty acids, C16-18 (even numbered) and C16-18-unsatd. (even numbered), triesters with trimethylolpropane (CAS 68002-79-9), is available. The study was performed according to OECD 301F (Manometric Respirometry; Börner, 2000). Sewage effluent was used as inoculum. A degradation of 86% within 28 days was observed and the 10-day window was fulfilled. In conclusion, the source substance is readily biodegradable according to OECD criteria.
One study, investigating the ready biodegradability of the source substance Fatty acids, C8-10(even), C14-18(even) and C16-18(even)-unsatd., triesters with trimethylolpropane (former CAS 85186-89-6), is available. The study was performed according to EU Method C.4-C (GLP) using domestic activated sludge (non-adapted) as inoculum (Bealing and Watson, 2001). At test termination after 28 days, the test substance was degraded to 77%. The 10-day-window was fulfilled. Therefore, the source substance is readily biodegradable according to the OECD criteria.
Supporting (Q)SAR predictions using VEGA v1.0.8 showed that the main components of the UVCB target substance are readily biodegradable. The prediction is valid and reliable as all constituents are within the training set of the model. Similar molecules with experimental data were found within the training set showing that the substance is readily biodegradable. This result supports the experimental study with structurally very similar source substances as discussed above.
Based on the reliable results from several structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) it can be concluded that 2-ethyl-2-(hydroxymethyl)-1,3-propanediyl dioleate is readily biodegradable according to the OECD criteria.
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