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EC number: 200-819-5 | CAS number: 74-88-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 July 2010 to 05 August 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.57
- Temp.:
- 20 °C
- pH:
- >= 5.45 - <= 6.03
- Details on results:
- - The recovery of the QC sample analysed along with the n-octanol-saturated aqueous phases was 96.4 %. The stock solution in n-octanol showed a concentration of 1172 mg a.i./L, which is 119 % of the expected value.
- The recovery of the QC samples (in n-octanol) analysed along with the water-saturated noctanol phase was 130 %. This high values most likely due to an error during the preparation
of the sample. The QC prepared for the water samples and the measurement of the stock solution confirmed the validity of the analytical method used.
- The concentration of the test material found in the aqueous phase was between 28.1 and 31.1 mg a.i./L. The concentration in the n-octanol phase ranged from 1021 to 1285 mg a.i./L. The
calculated mean log Kow is thus 1.57. The log Kow results were within the accepted range of ± 0.3 units. The measured pH ranged from 5.45 to 6.03.
- The log Kow value obtained from the literature of 1.5 is similar to the log Kow found during this study. - Conclusions:
- Under the conditions of this study, the log Kow of the test material was 1.57.
- Executive summary:
The partition coefficient of the test material was investigated in accordance with the standardised guideline OECD 107, under GLP conditions using the shake-flask method with HPLC.
The concentration of the test material found in the aqueous phase was between 28.1 and 31.1 mg a.i./L. The concentration in the n-octanol phase ranged from 1021 to 1285 mg a.i./L. The calculated mean log Kow is thus 1.57. The log Kow results were within the accepted range of ± 0.3 units. The measured pH ranged from 5.45 to 6.03. The log Kow value obtained from the literature of 1.5 is similar to the log Kow found during this study.
Under the conditions of this study, the log Kow of the test material was 1.57.
Reference
Description of key information
Under the conditions of this study, the log Kow of the test material was 1.57.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.57
- at the temperature of:
- 20 °C
Additional information
The partition coefficient of the test material was investigated in accordance with the standardised guideline OECD 107, under GLP conditions using the shake-flask method with HPLC. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
The concentration of the test material found in the aqueous phase was between 28.1 and 31.1 mg a.i./L. The concentration in the n-octanol phase ranged from 1021 to 1285 mg a.i./L. The calculated mean log Kow is thus 1.57. The log Kow results were within the accepted range of ± 0.3 units. The measured pH ranged from 5.45 to 6.03. The log Kow value obtained from the literature of 1.5 is similar to the log Kow found during this study.
Under the conditions of this study, the log Kow of the test material was 1.57.
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