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EC number: 222-960-1 | CAS number: 3681-71-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: An adaptation of the repeated insult patch test procedure suggested by Draize (Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics, published 1959 by The Association of Food and Drug Officials of the United States, p.52).
- GLP compliance:
- no
- Remarks:
- Study predates GLP.
- Type of study:
- patch test
Test material
- Reference substance name:
- (Z)-hex-3-enyl acetate
- EC Number:
- 222-960-1
- EC Name:
- (Z)-hex-3-enyl acetate
- Cas Number:
- 3681-71-8
- Molecular formula:
- C8H14O2
- IUPAC Name:
- (Z)-hex-3-enyl acetate
- Details on test material:
- - Name of test material (as cited in study report): SC-1167V
- Physical state: clear, odorous liquid
Constituent 1
In vivo test system
Test animals
- Species:
- human
- Sex:
- male/female
- Details on test animals and environmental conditions:
- - Type of population: general
- Number of subjects exposed: 43 subjects, of whom 38 completed the program
- Age: 16 to >60
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
Challenge
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
Results and discussion
Any other information on results incl. tables
The individual reaction scores and group totals for each scoring are as follows. The columns A and A' designate first and second scorings of the challenge.
Subject |
Applications |
||||||||||
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
A |
A’ |
|
1 |
0 |
0 |
0 |
0 |
- |
*0 |
0 |
0 |
0 |
0 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
4 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
5 |
0 |
0 |
0 |
0 |
- |
*0 |
0 |
0 |
0 |
0 |
0 |
6 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
7 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
8 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
9 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
10 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
11 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
12 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
13 |
0 |
0 |
0 |
0 |
0 |
- |
*0 |
0 |
0 |
0 |
0 |
14 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
15 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
17 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
18 |
Dropped |
||||||||||
19 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
21 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
22 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
23 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
24 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
25 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
26 |
0 |
- |
*0 |
0 |
0 |
Dropped |
|||||
27 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
28 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
29 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
30 |
0 |
0 |
Dropped |
||||||||
31 |
- |
*0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
32 |
0 |
- |
*0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
33 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
34 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
35 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
36 |
0 |
0 |
0 |
R0 |
R0 |
R0 |
R0 |
R0 |
- |
0 |
0 |
37 |
Dropped |
||||||||||
38 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
39 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
40 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
41 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
42 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
43 |
0 |
0 |
0 |
Dropped |
Totals
0 |
40 |
38 |
38 |
39 |
37 |
35 |
37 |
38 |
26 |
37 |
35 |
NP |
1 |
3 |
2 |
0 |
2 |
3 |
1 |
0 |
12 |
1 |
3 |
-= Subject absent
*= Residual reaction to earlier application, after absence, not included in the score totals.
R= Applied to second site because of tape reaction or for other reason irrelevant to test.
NP= Number of subjects no included in score totals (-, *)
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- The irrative properties of the test substance on human skin and whether it tends to cause sensitization reactions was determined according to an adaptation of the insult patch test procedure suggested by Draize (1959). Under the conditions of this study the test substance caused no primary irritation. None of the 38 subjects tested were sensitised by the sample of the test substance.
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