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EC number: 222-960-1 | CAS number: 3681-71-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: An adaptation of the repeated insult patch test procedure suggested by Draize (Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics, published 1959 by The Association of Food and Drug Officials of the United States, p.52).
- GLP compliance:
- no
- Remarks:
- Study predates GLP.
- Type of study:
- patch test
Test material
- Reference substance name:
- (Z)-hex-3-enyl acetate
- EC Number:
- 222-960-1
- EC Name:
- (Z)-hex-3-enyl acetate
- Cas Number:
- 3681-71-8
- Molecular formula:
- C8H14O2
- IUPAC Name:
- (Z)-hex-3-enyl acetate
- Details on test material:
- - Name of test material (as cited in study report): SC-1167V
- Physical state: clear, odorous liquid
Constituent 1
In vivo test system
Test animals
- Species:
- human
- Sex:
- male/female
- Details on test animals and environmental conditions:
- - Type of population: general
- Number of subjects exposed: 43 subjects, of whom 38 completed the program
- Age: 16 to >60
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
Challenge
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
Results and discussion
Any other information on results incl. tables
The individual reaction scores and group totals for each scoring are as follows. The columns A and A' designate first and second scorings of the challenge.
Subject |
Applications |
||||||||||
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
A |
A’ |
|
1 |
0 |
0 |
0 |
0 |
- |
*0 |
0 |
0 |
0 |
0 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
4 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
5 |
0 |
0 |
0 |
0 |
- |
*0 |
0 |
0 |
0 |
0 |
0 |
6 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
7 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
8 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
9 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
10 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
11 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
12 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
13 |
0 |
0 |
0 |
0 |
0 |
- |
*0 |
0 |
0 |
0 |
0 |
14 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
15 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
17 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
18 |
Dropped |
||||||||||
19 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
21 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
22 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
23 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
24 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
25 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
26 |
0 |
- |
*0 |
0 |
0 |
Dropped |
|||||
27 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
28 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
29 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
30 |
0 |
0 |
Dropped |
||||||||
31 |
- |
*0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
32 |
0 |
- |
*0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
33 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
34 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
35 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
36 |
0 |
0 |
0 |
R0 |
R0 |
R0 |
R0 |
R0 |
- |
0 |
0 |
37 |
Dropped |
||||||||||
38 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
39 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
40 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
41 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
42 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
43 |
0 |
0 |
0 |
Dropped |
|||||||
Totals
0 |
40 |
38 |
38 |
39 |
37 |
35 |
37 |
38 |
26 |
37 |
35 |
NP |
1 |
3 |
2 |
0 |
2 |
3 |
1 |
0 |
12 |
1 |
3 |
-= Subject absent
*= Residual reaction to earlier application, after absence, not included in the score totals.
R= Applied to second site because of tape reaction or for other reason irrelevant to test.
NP= Number of subjects no included in score totals (-, *)
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- The irrative properties of the test substance on human skin and whether it tends to cause sensitization reactions was determined according to an adaptation of the insult patch test procedure suggested by Draize (1959). Under the conditions of this study the test substance caused no primary irritation. None of the 38 subjects tested were sensitised by the sample of the test substance.
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