Registration Dossier
Registration Dossier
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EC number: 309-798-8 | CAS number: 101012-97-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented study report, which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
- Principles of method if other than guideline:
- BASF test
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Tridecanamine, N-tridecyl-, branched and linear
- EC Number:
- 309-798-8
- EC Name:
- Tridecanamine, N-tridecyl-, branched and linear
- Cas Number:
- 101012-97-9
- Molecular formula:
- C24 H50 NH - C28 H58 NH
- IUPAC Name:
- (2-methyldodecyl)(tridecyl)amine; ditridecylamine
- Details on test material:
- - Name of test material (as cited in study report): Ditridecylamin techn., Isomerengemisch
- Physical state: liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Kisslegg
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 0.1 - 30% emulsion with traganth
- Doses:
- 12.5, 16, 20, 25, 100, 200, 1600 mm³/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 10 mg/kg bw
- Remarks on result:
- other: Original data: 13 mm³/kg
- Mortality:
- All animals died at the concentrations of 16 mm³/kg and higher (equivalent to a concentration of ca. 12.3 mg/kg). At 12.5 mm³/kg (equivalent to a concentration of ca. 9.6 mg/kg) none of the males died compared to 3 of the females.
- Clinical signs:
- Dyspnea, staggering, atony, apathy and slight twitching
- Gross pathology:
- Sporadically, adhesions in the upper abdomen
Applicant's summary and conclusion
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