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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1970
Report date:
1970

Materials and methods

Principles of method if other than guideline:
BASF test (Inhalation hazard test)
The test was performed in priniple as described in OECD Guideline 403. The test demonstrates the toxicity of an atmosphere saturated with vapours of the volatile components of a test substance at the temerature chosen for vapour generation (20°C). 3 rats per sex were exposed sequentially to the vapours, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted gassdisc in a glass cylinder for 8h. The documentation of clinical signs was performed over a period of 7 days. In order toverify the results, the test was repeated once.
GLP compliance:
no
Test type:
other: Inhalation-risk test (IRT)
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Tridecanamine, N-tridecyl-, branched and linear
EC Number:
309-798-8
EC Name:
Tridecanamine, N-tridecyl-, branched and linear
Cas Number:
101012-97-9
Molecular formula:
C24 H50 NH - C28 H58 NH
IUPAC Name:
Tridecanamine, N-tridecyl-, branched and linear
Details on test material:
- Name of test material (as cited in study report): Ditridecylamin techn.
- Physical state: liquid
- Analytical purity:

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Temperature in air chamber: 20°C
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
no data
No. of animals per sex per dose:
6
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 7days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, histopathology

Results and discussion

Effect levels
Sex:
male/female
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
other: no mortality (saturated vapour concentration)
Mortality:
No mortality was observed.
Clinical signs:
other: Moderate irritation to the mucosa.
Gross pathology:
No abnormalities detected.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification