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Ecotoxicological information

Long-term toxicity to fish

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The Substance is poorly soluble in water and long-term toxicity testing should be considered according to REACH Regulation, Section 9.1.3, Column 2. However, the Registrant will not perform a study on the long-term toxicity to fish, but adapt the information requirements as follows. The Registrant wants to emphasize that with regard to the available acute toxicity data for DTDA, aquatic invertebrates are more sensitive to the Substance than fish. Even if the short-term toxicity data might not give a true measure of the toxicity of this poorly water-soluble substance, the data still reflect the relative sensitivity of the organisms to the Substance. The 96-h LL50 for fish was determined to be > 100 mg/L, while the effect levels for aquatic invertebrates and algae were lower (aquatic invertebrates: 48-h EL50 = 46.9 mg/L; algae: 72-h ErL50 = 12.3 mg/L). Avoiding unnecessary testing of vertebrate animals is in line with the REACH Regulation 1907/2006, which states in §25 that testing on vertebrate animal shall be undertaken as a last resort. Therefore, the testing strategy aims at investigating the long-term toxicity on aquatic invertebrates in a first step. Depending on the outcome of this test, a long-term study on fish will be performed.