Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation
Remarks:
other: QSAR
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
March 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Generally recogized OECD toolbox was used to establish skin sensitising properties
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
QSAR analysis was done using the OECD toolbox.
GLP compliance:
no
Type of study:
other: OECD toolbox

Test material

Constituent 1
Chemical structure
Reference substance name:
Nitrilotriacetonitrile
EC Number:
230-804-9
EC Name:
Nitrilotriacetonitrile
Cas Number:
7327-60-8
Molecular formula:
C6H6N4
IUPAC Name:
2-[bis(cyanomethyl)amino]acetonitrile

In vivo test system

Test animals

Species:
other: QSAR
Strain:
other: QSAR
Sex:
not specified

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
other: QSAR
Vehicle:
other: QSAR
Concentration / amount:
Not applicable
Challengeopen allclose all
Route:
other: QSAR
Vehicle:
other: QSAR
Concentration / amount:
Not applicable
No. of animals per dose:
Not applicable

Results and discussion

In vivo (non-LLNA)

Results
Reading:
other: QSAR
Hours after challenge:
0
Group:
other: QSAR
Dose level:
not applicable
No. with + reactions:
0
Total no. in group:
0
Clinical observations:
based on chemical structure, skin sensitisation is not very likely
Remarks on result:
other: Reading: other: QSAR. . Hours after challenge: 0.0. Group: other: QSAR. Dose level: not applicable. No with. + reactions: 0.0. Total no. in groups: 0.0. Clinical observations: based on chemical structure, skin sensitisation is not very likely.

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information
Conclusions:
Based on QSAR, it is very unlikely that NTAN has skin sensitising properties.