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EC number: 216-768-7 | CAS number: 1663-39-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- strong effect of the test substance concentration in vehicle on mortality
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1963
Materials and methods
- Principles of method if other than guideline:
- BASF Test: Several groups of 5 or 10 mice per dose were treated intraperitoneally with preparations of the test substance in 2, 8, 10 and 20 % traganth, respectively. Group-wise documentation of clinical signs was performed over the 7-day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose. The clinical signs and findings were reported in summary form. On the basis of the observed lethality, the LD50 value was estimated or determined using a graphical evaluation of the dose response curve on probability paper.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- tert-butyl acrylate
- EC Number:
- 216-768-7
- EC Name:
- tert-butyl acrylate
- Cas Number:
- 1663-39-4
- Molecular formula:
- C7H12O2
- IUPAC Name:
- tert-butyl acrylate
Constituent 1
- Specific details on test material used for the study:
- tert. Butylacrylate, stabilized with 0.02 % hydroquinone
Test animals
- Species:
- mouse
- Strain:
- other: "Tuebinger" mice
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males: 24-36 g; females 18 - 28 g
ENVIRONMENTAL CONDITIONS
not reported
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: aqueous emulsion with traganth
- Doses:
- ca. 174, 348, 696, 870, 1088 and 1392 mg/kg (corresponding to 0.2, 0.4, 0.8, 1.0, 1.25 and 1.6 mL/kg, calculated with a density of 0.87 g/mL)
- No. of animals per sex per dose:
- 5 (except the lowest and highest dose: here, in total 5 animals of both sexes were tested per dose)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations: daily on workdays
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
- Mortality:
- All animals died in treatments with >=10% test substance concentration in vehicle (i.e. 696 - 1392 mg/kg) within 24 hrs, while no animal died in treatments with <=8% test substance concentration in vehicle (i.e. 174 - 696 mg/kg).
- Clinical signs:
- After the injection: strong staggering, abdominal position, jump convulsions, nodding spasms, dyspnoe, cyanosis, clonic-tonic convulsions, convulsive tremor, sunken flanks. Survivors recovered at least within 2 days.
- Body weight:
- not observed
- Gross pathology:
- nothing abnormal found
Applicant's summary and conclusion
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