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EC number: 216-768-7 | CAS number: 1663-39-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- observation period only 7 days
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- In principle, the methods described in OECD Guideline 401 were used. Several groups of 5 and 10 rats per dose respectively were treated by gavage with preparations of the test substance in aqueous solutions with traganth. Group-wise documentation of clinical signs was performed over the 7-day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose. The clinical signs and findings were reported in summary form.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- tert-butyl acrylate
- EC Number:
- 216-768-7
- EC Name:
- tert-butyl acrylate
- Cas Number:
- 1663-39-4
- Molecular formula:
- C7H12O2
- IUPAC Name:
- tert-butyl acrylate
Constituent 1
- Specific details on test material used for the study:
- tert. Butylacrylate, stabilized with 0.02 % hydroquinone
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: own breeding
- Weight at study initiation: males: 112 - 274 g; females 108 - 200 g
ENVIRONMENTAL CONDITIONS
not reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous suspension with traganth
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2 - 30 %
MAXIMUM DOSE VOLUME APPLIED: 21.3 cm3/kg bw in the 5581 mg/cm3 treatment - Doses:
- approx. 174; 558; 872; 1090; 1395; 1744; 2180; 2790; 5581 mg/kg bw (calculated with a density of ca. 0.87 g/cm3; original data: 200, 640, 1000, 1250, 1600, 2000, 2500, 3200 and 6400 µL/kg bw)
- No. of animals per sex per dose:
- 5 per dose or 5 per sex per dose (see result table)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days (except the treatment group of 1090 mg/kg bw, 20 % concentration: 12 d)
- Frequency of observations: daily on workdays
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- not performed
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 047 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original data: ca 1200 µL/kg bw
- Mortality:
- Mortality mostly occurred within the first two days after dosing. Animals which survived recovered within day 2 to 4. For more details see table below.
- Clinical signs:
- other: Dyspnoea, convulsive chewing, spastic gait, saltatory spasms, rolling convulsions, abdominal/lateral position several hours after application.
- Gross pathology:
- Nothing abnormal found on necropsy.
Any other information on results incl. tables
Cumulated mortality:
Dose 1hr 24hrs 48hrs 7days
174 mg/kg
0/5 0/5 0/5 0/5
558 mg/kg 0/5 0/5 0/5 0/5
872 mg/kg 0/15 1/15 2/15 2/15
1090 mg/kg 0/20 7/20 8/20 11/20
1395 mg/kg 0/20 12/20 12/20 11/20*
1744 mg/kg 0/10 7/10 7/10 7/10
2180 mg/kg 0/10 7/10 8/10 8/10
2790 mg/kg 0/10 10/10 10/10 10/10
5581 mg/kg 0/10 10/10 10/10 10/10
*12/20 after 12 d
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
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