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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Limited documentation

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Toxicity of phenylhydrazine in inhalatory exposure
Author:
Pham KC
Year:
1979
Bibliographic source:
Gigiena Truda i Professional'nye Zabolevaniya, 3:45-47; cited in BUA (1995) Phenylhydrazine. Stuttgart, S. Hirzel, Wissenschaftliche Verlagsgesellschaft (Report No. 120; ISBN 3-7776-0691-X).
Reference Type:
publication
Title:
Toxicity of phenylhydrazine in inhalatory exposure
Author:
Pham KC
Year:
1979
Bibliographic source:
Gigiena Truda i Professional'nye Zabolevaniya, 3:45-47; cited in WHO 2000, Phenylhydrazine. CICAD 19, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, ISBN 92 4 153019 7; ISSN 1020-6167.
Reference Type:
secondary source
Title:
Concise International Assessment Document 19: Phenylhydrazine
Author:
WHO
Year:
2000
Bibliographic source:
Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, ISBN 92 4 153019 7; ISSN 1020-6167
Reference Type:
secondary source
Title:
Unnamed
Year:
1994

Materials and methods

Principles of method if other than guideline:
Determination of LC50 values for an unstated exposure period.
GLP compliance:
no
Test type:
other: Inhalation procedure with whole body exposure

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
other: no data
Details on inhalation exposure:
no data
Analytical verification of test atmosphere concentrations:
not specified
Remarks on duration:
no data
Concentrations:
No data about the tested concentrations. According to the original publication LC50 was 2.61 +/- 0.37 mg/L.
Cited in WHO 2000, LC50 was determined as 2745 mg/m³ (610 ppm).
Cited in UBA 1994, LC50 was identical to the original publication (2.61 +/- 0.37 mg/L).
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
No statistics was performed.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
2.61 mg/L air
Remarks on result:
other: no data about exposure duration
Mortality:
no details
Clinical signs:
other: respiratory disorder such as other methemoglobin formers
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion