Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 214-029-3 | CAS number: 1073-69-4
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: meets generally accepted scientific standards, well documented and acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Induction of Haemolytic Anaemia by Substituted Phenylhydrazines
- Author:
- Itano HA, Hosokawa K, Hirota K
- Year:
- 1 976
- Bibliographic source:
- British Journal of Haematology 33: 99-104
- Reference Type:
- publication
- Title:
- Mechanism of induction of haemolytic anaemia by phenylhydrazine
- Author:
- Itano HA, Hirota K, Hosokawa K
- Year:
- 1 975
- Bibliographic source:
- Nature 256: 665-667
Materials and methods
- Type of study / information:
- The induction of anaemia and reticulocytosis by 4-chlorophenylhydrazine and other substances was investigated.
- Principles of method if other than guideline:
- Female rabbits were used for the induction of anaemia and reticulocytosis. Subcutaneous injections were administered day 1 to 4 after a baseline sample of blood was taken. Additional samples of blood were taken 2, 5, and 7 days after the baseline sample. Packed cell volume, reticulocyte count and erythrocyte count were determined.
- GLP compliance:
- not specified
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): 4-chlorophenylhydrazine
no further data
Results and discussion
Any other information on results incl. tables
Unsubstituted phenylhydrazine was the most effective inducer of anaemia and reticulocytosis. The relative effectiveness of the substituted compounds corresponded primarily with position and secondarily with number of substituents.
The most effective of the substituted compounds were those with one or two chlorine atoms at ring positions meta (3- or 5 -) or para (4 -) to the hydrazino group, namely the 3- or 4 -chloro- and the 3,4- or 3,5 -dichlorophenylhydrazines.
4 -chlorophenylhydrazine was therefore an effective inducer of anaemia and reticulocytosis.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
