Registration Dossier
Registration Dossier
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EC number: 250-063-5 | CAS number: 30125-47-4
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- other: health surveillance data from routine checkups
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
- Study type:
- medical monitoring
- Endpoint addressed:
- repeated dose toxicity: inhalation
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,4,5,6-tetrachloro-N-[2-(4,5,6,7-tetrachloro-2,3-dihydro-1,3-dioxo-1H-inden-2-yl)-8-quinolyl]phthalimide
- EC Number:
- 250-063-5
- EC Name:
- 3,4,5,6-tetrachloro-N-[2-(4,5,6,7-tetrachloro-2,3-dihydro-1,3-dioxo-1H-inden-2-yl)-8-quinolyl]phthalimide
- Cas Number:
- 30125-47-4
- Molecular formula:
- C26H6Cl8N2O4
- IUPAC Name:
- 4,5,6,7-tetrachloro-2-[2-(4,5,6,7-tetrachloro-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)quinolin-8-yl]-1H-isoindole-1,3(2H)-dione
- Test material form:
- solid: nanoform
- Details on test material:
- - Physical state/ appearance: solid / yellow
- Shape of particles: spherical
- Aspect ratio: 1.5
- Particle size distribution: 62.7 nm
- Crystal structure: crystalline
- Surface area of particles: 29.6 m^2/g
- Surface treatment: no
Constituent 1
- Specific details on test material used for the study:
- Pigments of the chemical class Isonindolinone and Perylene
Method
- Type of population:
- other: worker
- Ethical approval:
- not applicable
- Details on study design:
- The company offers routine health checkups for all employees. Within the last 20 years more than 200 worker operating at this pigment production site have been checked. In summary more than 2000 single checkups were performed.
A routine health checkup includes examination of eye-sight, pulmonary function, hearing and general parameters:
- test for acuteness of vision
- spirometrie
- audiometry
- body weight
- blood pressure
- hemogram
- urinalysis
Results and discussion
- Results:
- In the cause of the employment medical examination within the last years, no need for an occupational health specific action arised.
Additionally, there was also no event which provoked an adaption of the existing safety precausions.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
