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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Date of Study Report: August 25, 1976
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given: comparable to guidelines/standards

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: 16CFR 1500.40
Deviations:
not specified
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
- Name of test material (as cited in study report): Diallyl phthalate
- Analytical purity: 99 %
- Other:
- Identified as C8013-3

Test animals

Species:
rabbit
Strain:
other: albino
Sex:
not specified
Details on test animals and environmental conditions:
The acute dermal toxicity study (single exposure) was conducted on adult albino rabbits selected from healthy, acclimated animals.

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
No details provided in report
Duration of exposure:
No details provided in report
Doses:
200, 2000 and 5000 mg/kg
No. of animals per sex per dose:
30 rabbits used in total (no details provided whether they were male or female)
Control animals:
not specified
Details on study design:
No details provided in report
Statistics:
No details provided in report

Results and discussion

Preliminary study:
N/A
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 300 mg/kg bw
Based on:
test mat.
Mortality:
No details provided in report
Clinical signs:
No details provided in report
Body weight:
No details provided in report
Gross pathology:
No details provided in report
Other findings:
No details provided in report

Any other information on results incl. tables

Results:

 

Dosage Level

(mg/kg)

No.*Rabbits

Dosed

Deaths

Day

1

2

3

4

5

6

7

8

9

10

11

12

13

14

Mortality after 14 Days

200

10

3

0

0

0

0

0

0

0

0

0

0

0

0

0

3/10

2000

10

1

0

0

1

0

0

0

1

0

0

0

1

0

0

4/10

5000

10

1

2

3

0

0

0

0

0

0

0

0

0

0

0

6/10

* Administered as received.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Remarks:
Migrated information
Conclusions:
The approximate acute Dermal LD50 obtained for the test material identified above is 3300 mg/kg of body weight estimated by interpolation from the probit response curve.